The influence of the extraction method on polyphenols, flavonoids composition and anti-hyperlipidemic properties of papaya leaves (Carica papaya Linn.)

Abstract Background Papaya ( Carica papaya Linn.) is well known for its nutritional as medicinal value. Different parts of the plant including leaves have been used therapeutic remedies various diseases. The objective present study to determine impact different extraction methods; microwave-assisted, ultrasonic-assisted and conventional maceration on extract yield, polyphenols, flavonoids composition subsequently, anti-hyperlipidemic potential Linn.). Results Innovative methods represented in microwave assisted (MAE) ultrasonic (UAE) significant yield total phenolic content than (CME) prepared aqueous ethanol extracts. HPLC assay showed highest bioactive polyphenols characterized from MAE (29.99 mg/g), followed by UAE (24.75 mg/g) lowest was that obtained CME. induced hypolipidemic activity P < 0.05) hyperlipidemic rats particularly, oral treatment with 200 mg/kg b.wt. which retained lipid profile be compatible results receiving simvastatin (0.18 b.w.). Conclusion substantiate traditional usage recommend utilization its’ beneficial effects.